Okudaira Noriyuki

Researcher Information

Affiliation

Preclinical Medicine Senior Assistant Professor
Department of Biochemistry Senior Assistant Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201701003134243252

J-Global ID

• 201701003134243252

Profile

• 最終学歴：筑波大学大学院人間総合科学研究科生命システム医学専攻（医学博士）

Research Interests

• 老化   ヘテロサイクリックアミン   発がん機構   LINE-1   retroelement   

Research Areas

• Life sciences / Cell biology / 老化
• Life sciences / Medical biochemistry
• Life sciences / Genomics

Academic & Professional Experience

• 2025/04 - Today  Teikyo University
• 2015/09 - 2020/03  Meikai UniversitySchool of Dentistry
• 2012/04 - 2015/03  Hyogo College of MedicineFaculty of Medicine

Research Activity Information

Published Papers

• Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion.

  Noriyuki Okudaira; Mi-Ho Akimoto; Takao Susa; Miho Akimoto; Harumi Hisaki; Masayoshi Iizuka; Hiroko Okinaga; Julio A Almunia; Noboru Ogiso; Tomoki Okazaki; Mimi Tamamori-Adachi

  Aging cell e14206  2024/05 [Refereed]
  
• Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.

  Miho Akimoto; Takao Susa; Noriyuki Okudaira; Nobuko Koshikawa; Harumi Hisaki; Masayoshi Iizuka; Hiroko Okinaga; Keizo Takenaga; Tomoki Okazaki; Mimi Tamamori-Adachi

  Proceedings of the National Academy of Sciences of the United States of America 120 (18) e2218033120  2023/05
• アンドロゲン受容体およびスプライシングバリアントに対するHOXC9阻害作用の解析

  諏佐 崇生; 坪井 栄希; 秋元 美穂; 奥平 准之; 飯塚 眞由; 岡崎 具樹; 安達 三美[玉盛]

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 95回 1T11a - 08 2022/11
• 加齢に伴うマウスコルチコステロンの日内リズム破綻のメカニズムの解析

  奥平 准之; 秋元 美穂; 諏佐 崇生; 小原 幸弘; 久樹 晴美; 飯塚 眞由; 岡崎 具樹; 安達 三美[玉盛]

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 95回 1T14a - 04 2022/11
• A Novel LncRNA PTH-AS Upregulates Interferon-Related DNA damage resistance Signature genes and Promotes Metastasis in Human Breast Cancer Xenografts.

  Miho Akimoto; Takao Susa; Noriyuki Okudaira; Harumi Hisaki; Masayoshi Iizuka; Hiroko Okinaga; Tomoki Okazaki; Mimi Tamamori-Adachi

  The Journal of biological chemistry 298 (7) 102065 - 102065 2022/05
• Resveratrol blocks retrotransposition of LINE-1 through PPAR α and sirtuin-6.

  Noriyuki Okudaira; Yukihito Ishizaka; Mimi Tamamori-Adachi

  Scientific reports 12 (1) 7772 - 7772 2022/05
• ヒト前立腺癌細胞にてDHTで抑制されるHOXC9はARの阻害因子として機能する

  諏佐 崇生; 秋元 美穂; 奥平 准之; 飯塚 眞由; 岡崎 具樹; 安達 三美

  日本内分泌学会雑誌 (一社)日本内分泌学会 98 (1) 295 - 295 0029-0661 2022/04
• 1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)-4-Piperidone hydrochloride and Related Compounds: Potent Cytotoxins Demonstrating Greater Toxicity to Neoplasms Than Non-Malignant Cells.

  Praveen Kumar Roayapalley; Jonathan R Dimmock; Hiroshi Sakagami; Noriyuki Okudaira; Rajendra K Sharma; Umashankar Das

  Medicinal chemistry (Shariqah (United Arab Emirates)) 18 (9) 1001 - 1012 2022/03 [Refereed]
  
• 加齢に伴うマウスコルチコステロン濃度の変化と制御機構

  奥平 准之; 秋元 美穂; 諏佐 崇生; 久樹 晴美; 飯塚 眞由; 岡崎 具樹; 安達 三美[玉盛]

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 94回 [P - 778] 2021/11
• 加齢に伴うマウスコルチコステロン濃度の変化と制御機構

  奥平 准之; 秋元 美穂; 諏佐 崇生; 久樹 晴美; 飯塚 眞由; 岡崎 具樹; 安達 三美[玉盛]

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 94回 [P - 778] 2021/11
• Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro

  MICHITO TERATANI; SHOUTA NAKAMURA; HIROSHI SAKAGAMI; MASAKAZU FUJISE; MASASHI HASHIMOTO; NORIYUKI OKUDAIRA; KENJIRO BANDOW; YOSUKE IIJIMA; JUNKO NAGAI; YOSHIHIRO UESAWA; HIDETSUGU WAKABAYASHI

  Anticancer Research Anticancer Research USA Inc. 40 (9) 4885 - 4894 0250-7005 2020/09
• Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.

  Kana Imanari; Masashi Hashimoto; Hidetsugu Wakabayashi; Noriyuki Okudaira; Kenjiro Bandow; Junko Nagai; Mineko Tomomura; Akito Tomomura; Yoshihiro Uesawa; Hiroshi Sakagami

  Anticancer research 39 (7) 3507 - 3518 2019/07 [Refereed]
  
• Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates

  Gul HI; Yamali C; Gunesacar G; Sakagami H; Okudaira N; Uesawa Y; Kagaya H

  Medicinal Chemistry 27 (10) 2366 - 2378 1554-8120 2018/10 [Refereed]
  
• Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.

  Haixia Shi; Junko Nagai; Tsukasa Sakatsume; Kenjiro Bandow; Noriyuki Okudaira; Yoshihiro Uesawa; Hiroshi Sakagami; Mineko Tomomura; Akito Tomomura; Koichi Takao; Yoshiaki Sugita

  Anticancer research 38 (8) 4459 - 4467 2018/08 [Refereed]
  
• Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones.

  Junko Nagai; Haixia Shi; Yuka Kubota; Kenjiro Bandow; Noriyuki Okudaira; Yoshihiro Uesawa; Hiroshi Sakagami; Mineko Tomomura; Akito Tomomura; Koichi Takao; Yoshiaki Sugita

  Anticancer research 38 (8) 4449 - 4457 2018/08 [Refereed]
  
• Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.

  Haixia Shi; Junko Nagai; Tsukasa Sakatsume; Kenjiro Bandow; Noriyuki Okudaira; Hiroshi Sakagami; Mineko Tomomura; Akito Tomomura; Yoshihiro Uesawa; Koichi Takao; Yoshiaki Sugita

  Anticancer research 38 (7) 3897 - 3906 2018/07 [Refereed]
  
• Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.

  Yoshihiro Uesawa; Hiroshi Sakagami; Noriyuki Okudaira; Kazuhiro Toda; Koichi Takao; Hajime Kagaya; Yoshiaki Sugita

  Anticancer research 38 (2) 817 - 823 2018/02 [Refereed]
  
• Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.

  Hiroshi Sakagami; Noriyuki Okudaira; Yoshihiro Uesawa; Koichi Takao; Hajime Kagaya; Yoshiaki Sugita

  Anticancer research 38 (2) 763 - 770 2018/02 [Refereed]
  
• In Vitro Antitumor Activity of Alkylaminoguaiazulenes

  Uehara M; Minemura H; Ohno T; Hashimoto M; Wakabayashi H; Okudaira N; Sakagami H

  In Vivo 32 (3) 541 - 547 2018 [Refereed]
  
• In Vitro Anti-tumor Activity Azulene Amide Derivatuves.

  Wada T; Maruyama R; Irie Y; Hashimoto M; Wakabayashi H; Okudaira N; Uesawa Y; Kagaya H; Sakagami H

  In Vivo 32 (3) 479 - 486 0258-851X 2018 [Refereed]
  
• Synthesis and structure elucidation of 1-(2,5/3,5-difluorophenyl)-3-(2,3/2,4/2,5/3,4-dimethoxyphenyl)-2-propen-1-ones as anticancer agents

  Cem Yamali; Dilan Ozmen Ozgun; Halise Inci Gul; Hiroshi Sakagami; Cavit Kazaz; Noriyuki Okudaira

  MEDICINAL CHEMISTRY RESEARCH 26 (9) 2015 - 2023 1054-2523 2017/09 [Refereed]
  
• Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin

  Hiroshi Sakagami; Noriyuki Okudaira; Yoshiko Masuda; Osamu Amano; Satoshi Yokose; Yumiko Kanda; Madoka Suguro; Takenori Natori; Hiroshi Oizumi; Takaaki Oizumi

  ANTICANCER RESEARCH 37 (3) 1023 - 1029 0250-7005 2017/03 [Refereed]
  
• Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata

  Ryuichiro Suzuki; Yasuaki Matsushima; Noriyuki Okudaira; Hiroshi Sakagami; Yoshiaki Shirataki

  ANTICANCER RESEARCH 36 (11) 5931 - 5935 0250-7005 2016/11 [Refereed]
  
• Antiviral and Antitumor Activity of Licorice Root Extracts

  Kunihiko Fukuchi; Noriyuki Okudaira; Kazunori Adachi; Reina Odai-Ide; Shigeru Watanabe; Hirokazu Ohno; Masaji Yamamoto; Taisei Kanamoto; Shigemi Terakubo; Hideki Nakashima; Yoshihiro Uesawa; Hajime Kagaya; Hiroshi Sakagami

  IN VIVO 30 (6) 777 - 785 0258-851X 2016/11 [Refereed]
  
• Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone

  Yukiko Tomikoshi; Maki Nomura; Noriyuki Okudaira; Hiroshi Sakagami; Hidetsugu Wakabayashi

  IN VIVO 30 (5) 645 - 650 0258-851X 2016/09 [Refereed]
  
• Prominent Anti-UV Activity and Possible Cosmetic Potential of Lignin-carbohydrate Complex

  Hiroshi Sakagami; Hong Sheng; Noriyuki Okudaira; Toshikazu Yasui; Hidetsugu Wakabayashi; Junye Jia; Takenori Natori; Madoka Suguro-Kitajima; Hiroshi Oizumi; Takaaki Oizumi

  IN VIVO 30 (4) 331 - 339 0258-851X 2016/07 [Refereed]
  
• Morphine and Fentanyl Citrate Induce Retrotransposition of Long Interspersed Element-1

  Noriyuki Okudaira; Yukihito Ishizaka; Hajime Nishio; Hiroshi Sakagami

  In vivo (Athens, Greece) 30 (2) 113 - 118 1791-7549 2016/03
• Morphine and Fentanyl Citrate Induce Retrotransposition of Long Interspersed Element-1

  Noriyuki Okudaira; Yukihito Ishizaka; Hajime Nishio; Hiroshi Sakagami

  IN VIVO 30 (2) 112 - 117 0258-851X 2016/03 [Refereed]
  
• Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: A study using a knock-in mouse model

  Hajime Nishio; Noriyuki Okudaira; Kazufumi Matsushita; Tomohiro Yoshimoto; Takako Sato; Koichi Suzuki

  LEGAL MEDICINE 16 (6) 326 - 332 1344-6223 2014/11 [Refereed]
  
• Retrotransposition of Long Interspersed Element 1 Induced by Methamphetamine or Cocaine

  Noriyuki Okudaira; Yukihito Ishizaka; Hajime Nishio

  JOURNAL OF BIOLOGICAL CHEMISTRY 289 (37) 25476 - 25485 0021-9258 2014/09 [Refereed]
  
• A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes

  Noriyuki Okudaira; Masayoshi Kuwahara; Yutaka Hirata; Yoshitaka Oku; Hajime Nishio

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 452 (3) 665 - 668 0006-291X 2014/09 [Refereed]
  
• Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor

  N. Okudaira; T. Okamura; M. Tamura; K. Iijma; M. Goto; A. Matsunaga; M. Ochiai; H. Nakagama; S. Kano; Y. Fujii-Kuriyama; Y. Ishizaka

  Oncogene 32 (41) 4903 - 4912 0950-9232 2013/10 [Refereed]
  
• Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1

  Kenta Iijima; Noriyuki Okudaira; Masato Tamura; Akihiro Doi; Yoshikazu Saito; Mari Shimura; Motohito Goto; Akihiro Matsunaga; Yuki I. Kawamura; Takeshi Otsubo; Taeko Dohi; Shigeki Hoshino; Shigeyuki Kano; Shotaro Hagiwara; Junko Tanuma; Hiroyuki Gatanaga; Masanori Baba; Taku Iguchi; Motoko Yanagita; Shinichi Oka; Tadashi Okamura; Yukihito Ishizaka

  RETROVIROLOGY 10 83 - 83 1742-4690 2013/08 [Refereed]
  
• Regulation of retrotransposition of long interspersed element-1 by mitogen-activated protein kinases

  Ishizaka Y; Okudaira N; Okamura T

  Biochemistry, Genetics and Molecular Biology » "Protein Kinases", book edited by Gabriela Da Silva Xavier 187 - 198 2012/06 [Refereed]
  
• Modes of retrotransposition of long interspersed element-1 by environmental factors

  Yukihito Ishizaka; Noriyuki Okudaira; Masato Tamura; Kenta Iijima; Mari Shimura; Motohito Goto; Tadashi Okamura

  FRONTIERS IN MICROBIOLOGY 3 191 - 191 1664-302X 2012 [Refereed]
  
• Activation and mechanism of endogenous retroelement in intractable diseases

  Noriyuki Okudaira; Yukihito Ishizaka

  Seikagaku 84 (10) 870 - 874 0037-1017 2012 [Refereed]
  
• Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate

  Noriyuki Okudaira; Motohito Goto; Rieko Yanobu-Takanashi; Masato Tamura; Akihiro An; Yukiko Abe; Shigeyuki Kano; Shotaro Hagiwara; Yukihito Ishizaka; Tadashi Okamura

  CANCER SCIENCE 102 (11) 2000 - 2006 1347-9032 2011/11 [Refereed]
  
• Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoproduct

  Noriyuki Okudaira; Kenta Iijima; Takayoshi Koyama; Yuzuru Minemoto; Shigeyuki Kano; Akio Mimori; Yukihito Ishizaka

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107 (43) 18487 - 18492 0027-8424 2010/10 [Refereed]
  
• Comparison of the antioxidant activity of albumin from various animal species

  Toshio Okazaki; Noriyuki Okudaira; Naohito Ishii; Hiroshi Yotsuyanagi; Toshiaki Nagai; Shougo Tokudome; Takahiro Fujioka; Shinichiro Takahashi

  ZOOLOGICAL SCIENCE 25 (2) 172 - 177 0289-0003 2008/02 [Refereed]
  
• Apoptosis and adhesion of hemocytes during molting stage of silkworm, Bombyx mori

  T Okazaki; N Okudaira; K Iwabuchi; H Fugo; T Nagai

  ZOOLOGICAL SCIENCE 23 (3) 299 - 304 0289-0003 2006/03 [Refereed]
  

MISC

• Mechanisms of adrenal aging and enhancement of the Glucocorticoid-system

  奥平准之; 秋元美穂; 諏佐崇生; 秋元美穂; 小原幸弘; 久樹晴美; 飯塚眞由; 岡崎具樹; 安達(玉盛)三美  日本分子生物学会年会プログラム・要旨集(Web)  45th-  2022
• Vpr induces retrotransposition of long interspersed nucleotide element-1 in brain tissues: implication for HIV-1-induced dysfunction of CNS

  Noriyuki Okudaira; Motohito Goto; Junko Tanuma; Kenta Iijima; Tadashi Okamura; Hiroyuki Gatanaga; Shinichi Oka; Yukihito Ishizaka  EUROPEAN JOURNAL OF MEDICAL RESEARCH  15-  (8)  324  -325  2010/08

Research Grants & Projects

• 老化による副腎皮質組織のグルココルチコイド分泌撹乱とゲノム不安定性との連関性

  日本学術振興会：科学研究費助成事業 基盤研究(C)

  Date (from‐to) : 2023/04 -2026/03 

  Author : 奥平 准之
• Elucidation of selective cytotoxicity against malignant cells by chromone derivatives

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2020/04 -2023/03 

  Author : 坂上 宏; 田沼 靖一; 奥平 准之; 杉田 義昭; 佐藤 聡; 坂東 健二郎; 高尾 浩一; 天野 滋; 植沢 芳広
• Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2020/04 -2023/03 

  Author : 藤内 祝; 杉田 義昭; 友村 美根子; 坂上 宏; 坂東 健二郎; 山本 信治; 光藤 健司; 高尾 浩一; 小泉 敏之; 中鍛治 里奈; 天野 滋; 植沢 芳広; 坂下 英明; 奥平 准之
• 加熱食品由来発癌物質のゲノム不安定性作用に対するレスベラトロールの遺伝子制御機構

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2020/04 -2023/03 

  Author : 奥平 准之
• Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancer

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2016/04 -2019/03 

  Author : Sakagami Hiroshi; OKUDIRA NORIYUKI; BANDOW KENJIRO; NAGAI JUNKO
• βアミロイドによるLINE-1レトロエレメントの活性化機構

  特定非営利活動法人ヒューマンセンター21：平成29年度若手研究者育成の為の研究助成

  Date (from‐to) : 2017/11 -2018/10 

  Author : 奥平准之
• Long interspersed element-1 retrotransposition induced by abuse drugs

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2015/04 -2018/03 

  Author : OKUDAIRA Noriyuki
• 乱用薬物のLong Interspersed Element 1転移機構の解析

  科研費：若手研究B

  Date (from‐to) : 2015/04 -2018/03 

  Author : 奥平准之
• Long Interspersed Element 1の中枢神経機能への影響と薬物依存との関連性

  武田科学振興財団：医学系研究奨励

  Date (from‐to) : 2013/11 -2016/03 

  Author : 奥平准之
• Pathophysiological study of the mice with thymicolymphaticus-like phenotypes

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2013/04 -2016/03 

  Author : Nishio Hajime; Okudaira Noriyuki
• Long Interspersed Element 1の薬物依存形成機構に関する生物学的研究

  内藤記念科学振興財団：2013年度研究助成

  Date (from‐to) : 2013/11 -2015/03 

  Author : 奥平准之
• 法医解剖症例における胸腺リンパ体質と突然死の分子メカニズムの解析

  科研費：研究活動スタート支援

  Date (from‐to) : 2012/09 -2014/03 

  Author : 奥平准之
• カルシウム制御遺伝（RyR2）の免疫学的機能と突然死発症との連関性

  循環器学研究振興基金：2012年度研究助成

  Date (from‐to) : 2012/04 -2014/03 

  Author : 奥平准之
• Long Interspersed Element 1の中枢神経機能への影響

  公益財団法人 住友財団：2012年度基礎科学研究助成

  Date (from‐to) : 2012/04 -2013/03 

  Author : 奥平准之