Hakuba Nobuhiro

Researcher Information

Affiliation

Teikyo University Hospital, Mizonokuchi Professor
Department of Otorhinolaryngology  Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901099675091778

J-Global ID

• 200901099675091778

Research Areas

• Life sciences / Otorhinolaryngology

Education

•        - 1998  Ehime University
•        - 1998  Ehime University  Graduate School, Division of Medicine

Association Memberships

• 日本鼻科学会   日本耳科学会   耳鼻咽喉科臨床学会   日本耳鼻咽喉科学会   

Research Activity Information

MISC

• Local hypothermia in the treatment of idiopathic sudden sensorineural hearing loss.

  Auris Nasus Larynx.  16-  21  -26  2010
• Local hypothermia in the treatment of idiopathic sudden sensorineural hearing loss.

  Auris Nasus Larynx.  16-  21  -26  2010
• Basic Fibroblast Growth Factor Combined With Atelocollagen for Closing Chronic Tympanic Membrane Perforations in 87 Patients

  Nobuhiro Hakuba; Michitaka Iwanaga; Shinzo Tanaka; Yasuyuki Hiratsuka; Yohei Kumabe; Masaya Konishi; Yusuke Okanoue; Nao Hiwatashi; Tadahiko Wada  OTOLOGY & NEUROTOLOGY  31-  (1)  118  -121  2010/01
• Measurement of DPOAE after ischemia/reperfusion injury of the cochlea in gerbils

  Futoshi Watanabe; Nobuhiro Hakuba; Kiyofumi Gyo  NEUROSCIENCE LETTERS  467-  (2)  135  -138  2009/12
• Ischemic tolerance in the cochlea

  Shoichiro Takeda; Ryuji Hata; Fang Cao; Tadashi Yoshida; Nobuhiro Hakuba; Naohito Hato; Kiyofumi Gyo  NEUROSCIENCE LETTERS  462-  (3)  263  -266  2009/09
• Glutamate agonist causes irreversible degeneration of inner hair cells

  Jun Hyodo; Nobuhiro Hakuba; Naohito Hato; Shoichirou Takeda; Masahiro Okada; Yoshinori Omotehara; Kiyofumi Gyo  NEUROREPORT  20-  (14)  1255  -1259  2009/09
• Ear-pick injury as a traumatic ossicular damage in Japan

  Eur Arch Oto-Rhino -L  11-  (1)  111  -113  2009
• Prednisolone prevents transient ischemia-induced cochlear damage in gerbils

  Toshiki Maetani; Jun Hyodo; Shoichiro Takeda; Nobuhiro Hakuba; Gyo Kiyofumi  ACTA OTO-LARYNGOLOGICA  129-  24  -27  2009
• Ear-pick injury as a traumatic ossicular damage in Japan

  Eur Arch Oto-Rhino -L  11-  (1)  111  -113  2009
• Insulin-like growth factor I treatment via hydrogels rescues cochlear hair cells from ischemic injury

  Takashi Fujiwara; Naohito Hato; Takayuki Nakagawa; Yasuhiko Tabata; Tadashi Yoshida; Hayato Komobuchi; Shoichiro Takeda; Jun Hyodo; Nobuhiro Hakuba; Kiyofumi Gyo  NEUROREPORT  19-  (16)  1585  -1588  2008/10
• Postischemic mild hypothermia alleviates hearing loss because of transient ischemia

  Shoichiro Takeda; Nobuhiro Hakuba; Tadashi Yoshida; Kensuke Fujita; Naohito Hato; Ryuji Hata; Jun Hyodo; Kiyofumi Gyo  NEUROREPORT  19-  (13)  1325  -1328  2008/08
• Hematopoietic stem cells prevent hair cell death after transient cochlear ischemia through paracrine effects

  T. Yoshida; N. Hakuba; I. Morizane; K. Fujita; F. Cao; P. Zhu; N. Uchida; K. Kameda; M. Sakanaka; K. Gyo; R. Hata  NEUROSCIENCE  145-  (3)  923  -930  2007/03
• Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia

  Kensuke Fujita; Nobuhiro Hakuba; Ryuji Hata; Isao Morizane; Tadashi Yoshida; Masachika Shudou; Masahiro Sakanaka; Kiyofumi Gyo  NEUROSCIENCE LETTERS  415-  (2)  113  -117  2007/03
• Storage of the incus in the mastoid bowl for use as a columella in staged tympanoplasty

  Kiyofumi Gyo; Naoto Hato; Yusuke Shinomori; Nobuhiro Hakuba  AURIS NASUS LARYNX  34-  (1)  5  -8  2007/03
• Repair of a malleus-handle fracture using calcium phosphate bone cement

  Naohito Hato; Masahiro Okada; Nobuhiro Hakuba; Masamitsu. Hyodo; Kiyofumi Gyo  LARYNGOSCOPE  117-  (2)  361  -363  2007/02
• A new tool for testing ossicular mobility during middle ear surgery: Preliminary report of four cases

  Naohito Hato; Hisashi Kohno; Masahiro Okada; Nobuhiro Hakuba; Kiyofumi Gyo; Takashi Iwakura; Makoto Tateno  OTOLOGY & NEUROTOLOGY  27-  (5)  592  -595  2006/08
• Irinotecan (CPT-11) combined with cisplatin for small cell carcinoma of the nasal cavity

  N Hakuba; M Hyodo; T Yokoi; H Sato  AURIS NASUS LARYNX  33-  (1)  67  -70  2006/03
• Ischemic damage increases nitric oxide production via inducible nitric oxide synthase in the cochlea

  Morizane, I; N Hakuba; J Hyodo; Y Shimizu; K Fujita; T Yoshida; K Gyo  NEUROSCIENCE LETTERS  391-  (1-2)  62  -67  2005/12
• Kanamycin ototoxicity in glutamate transporter knockout mice

  Y Shimizu; H Hakuba; J Hyodo; M Taniguchi; K Gyo  NEUROSCIENCE LETTERS  380-  (3)  243  -246  2005/06
• Neural stem cells suppress the hearing threshold shift caused by cochlear ischemia.

  Neuroreport.  28-  (26)  1545  -1549  2005
• Transient cochlear ischemia and its effects on the stria vascularis.

  Neuroreport.  31-  (16)  799  -802  2005
• Neural stem cells suppress the hearing threshold shift caused by cochlear ischemia.

  Neuroreport.  28-  (26)  1545  -1549  2005
• Transient cochlear ischemia and its effects on the stria vascularis.

  Neuroreport.  31-  (16)  799  -802  2005
• Chondroma of the bony external auditory canal attached to the short process of the malleus

  K Gyo; S Kawakita; J Kobayashi; N Hakuba; S Matsumoto  INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY  68-  (11)  1441  -1444  2004/11
• Reconstruction of mastoid cortex defect using bone morphogenetic protein: An experimental study in the guinea pig

  A Sugimoto; N Hakuba; K Gyo  ACTA OTO-LARYNGOLOGICA  124-  (3)  253  -257  2004/03
• AMPA/kainate-type glutamate receptor antagonist reduces progressive inner hair cell loss after transient cochlear ischemia

  N Hakuba; A Matsubara; J Hyodo; M Taniguchi; T Maetani; Y Shimizu; Y Tsujiuchi; M Shudou; K Gyo  BRAIN RESEARCH  979-  (1-2)  194  -202  2003/07
• Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils

  N Hakuba; K Watabe; J Hyodo; T Ohashi; Y Eto; M Taniguchi; L Yang; J Tanaka; R Hata; K Gyo  GENE THERAPY  10-  (5)  426  -433  2003/03
• Free radical scavenger protects against inner hair cell loss after cochlear ischemia.

  Neuroreport.  6-  (14)  1881  -1884  2003
• A New Method for Closing Tympanic Membrane Perforations Using Basic Fibroblast Growth Factor.

  Laryngoscope  113(8):1352-5.  2003
• Free radical scavenger protects against inner hair cell loss after cochlear ischemia.

  Neuroreport.  6-  (14)  1881  -1884  2003
• Hearing loss and glutamate efflux in the perilymph following transcient hind brain ischemia in gerbils.

  The Journal of compurative neurology  418-  217  2000
• Hearing Loss and Glutamate Efflux in the Perilymph Following Transient Hindbrain Ischemia in Gerbil.

  Journal of Comparative Neurology.  418:217-226.  2000
• Exacerbation of noise-induced hearing loss in t mice lacking the glutamate transporter GLAST.

  The Journal of Neuroscience  20(23): 8750-8753.  2000
• Hearing loss and glutamate efflux in the perilymph following transcient hind brain ischemia in gerbils.

  The Journal of compurative neurology  418-  217  2000
• Efflnx of gluturate into the perilymph of the cochlea following transient is chemin in the gerbil

  HAKUBA N; GYO K; YANAGIHARA N; MITANI A; KATAOKA K  Neuroscience Letters  230-  (1)  69  -71  1997
• Efflnx of gluturate into the perilymph of the cochlea following transient is chemin in the gerbil

  Neuroscience Letters  230-  (1)  69  -71  1997

Awards & Honors

• 2003 日本耳科学会賞
   JPN
• 2003 耳鼻咽喉科臨床学会ポスター賞
   JPN
• 1999 耳鼻咽喉科臨床学会賞
   JPN

Research Grants & Projects

• 虚血性内耳障害
• Ischemic cochlear damage