Akimoto Miho

Researcher Information

Affiliation

Preclinical Medicine Senior Assistant Professor
Department of Biochemistry Senior Assistant Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201901017020016928

J-Global ID

• 201901017020016928

Research Interests

• 腫瘍生物学   細胞生物学   

Research Areas

• Life sciences / Cell biology
• Life sciences / Tumor biology

Academic & Professional Experience

• 2017/07 - Today  Teikyo UniversitySchool of Medicine
• 2006/05 - 2017/06  Shimane UniversityFaculty of Medicine

Association Memberships

• 日本分子生物学会   THE JAPANESE CANCER ASSOCIATION   

Research Activity Information

Published Papers

• Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion.

  Noriyuki Okudaira; Mi-Ho Akimoto; Takao Susa; Miho Akimoto; Harumi Hisaki; Masayoshi Iizuka; Hiroko Okinaga; Julio A Almunia; Noboru Ogiso; Tomoki Okazaki; Mimi Tamamori-Adachi

  Aging cell e14206  2024/05
• Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.

  Miho Akimoto; Takao Susa; Noriyuki Okudaira; Nobuko Koshikawa; Harumi Hisaki; Masayoshi Iizuka; Hiroko Okinaga; Keizo Takenaga; Tomoki Okazaki; Mimi Tamamori-Adachi

  Proceedings of the National Academy of Sciences of the United States of America 120 (18) e2218033120  2023/05 [Refereed]
  
• A Novel LncRNA PTH-AS Upregulates Interferon-Related DNA damage resistance Signature genes and Promotes Metastasis in Human Breast Cancer Xenografts

  Miho Akimoto; Takao Susa; Noriyuki Okudaira; Harumi Hisaki; Masayoshi Iizuka; Hiroko Okinaga; Tomoki Okazaki; Mimi Tamamori-Adachi

  Journal of Biological Chemistry Elsevier BV 102065 - 102065 0021-9258 2022/05 [Refereed]
  
• MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target.

  Keizo Takenaga; Nobuko Koshikawa; Miho Akimoto; Yasutoshi Tatsumi; Jason Lin; Makiko Itami; Hiroki Nagase

  Scientific reports 11 (1) 13302 - 13302 2021/06
• Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice.

  Keizo Takenaga; Miho Akimoto; Nobuko Koshikawa; Hiroki Nagase

  Scientific reports 11 (1) 2923 - 2923 2021/02
• 25(OH)D3 stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated.

  Takahiro Kikuyama; Takao Susa; Mimi Tamamori-Adachi; Masayoshi Iizuka; Miho Akimoto; Hiroko Okinaga; Yoshihide Fujigaki; Shunya Uchida; Shigeru Shibata; Tomoki Okazaki

  The Journal of steroid biochemistry and molecular biology 199 105593 - 105593 2020/05 [Refereed]
  
• Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model.

  Keizo Takenaga; Miho Akimoto; Nobuko Koshikawa; Hiroki Nagase

  PloS one 15 (4) e0232230  2020
• Role of the IL-33/ST2L axis in colorectal cancer progression.

  Miho Akimoto; Keizo Takenaga

  Cellular immunology 343 103740 - 103740 0008-8749 2019/09 [Refereed][Invited]
  
• Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis.

  Miho Akimoto; Riruke Maruyama; Yasunari Kawabata; Yoshitsugu Tajima; Keizo Takenaga

  Cell death & disease 9 (8) 804 - 804 2018/07 [Refereed]
  
• Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer.

  Nobuko Koshikawa; Miho Akimoto; Jun-Ichi Hayashi; Hiroki Nagase; Keizo Takenaga

  Scientific reports NATURE PUBLISHING GROUP 7 (1) 15535 - 15535 2045-2322 2017/11 [Refereed]
  
• HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression.

  Nanae Harashima; Keizo Takenaga; Miho Akimoto; Mamoru Harada

  Oncotarget IMPACT JOURNALS LLC 8 (26) 42887 - 42900 1949-2553 2017/06 [Refereed]
  
• Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment.

  Miho Akimoto; Riruke Maruyama; Hiroyuki Takamaru; Takahiro Ochiya; Keizo Takenaga

  Nature communications NATURE PUBLISHING GROUP 7 13589 - 13589 2041-1723 2016/11 [Refereed]
  
• Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer.

  Akimoto M; Hayashi JI; Nakae S; Saito H; Takenaga K

  Cell Death Dis Nature Publishing Group 7 (1) e2057  2041-4889 2016/01 [Refereed]
  
• Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death.

  Miho Akimoto; Mari Iizuka; Rie Kanematsu; Masato Yoshida; Keizo Takenaga

  PloS one PUBLIC LIBRARY SCIENCE 10 (5) e0126605  1932-6203 2015 [Refereed]
  
• Antitumor effect of Japanese apricot extract (MK615) on human cancer cells in vitro and in vivo through a reactive oxygen species-dependent mechanism

  Miho Hattori; Koshi Kawakami; Miho Akimoto; Keizo Takenaga; Junji Suzumiya; Yoshio Honma

  TUMORI PENSIERO SCIENTIFICO EDITOR 99 (2) 239 - 248 0300-8916 2013/03 [Refereed]
  
• Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells.

  Yoshihide Shimojo; Miho Akimoto; Tsunehiro Hisanaga; Tsuneo Tanaka; Yoshitsugu Tajima; Yoshio Honma; Keizo Takenaga

  Clinical & experimental metastasis 30 (2) 143 - 54 0262-0898 2013/02 [Refereed]
  
• An inhibitor of HIF-α subunit expression suppresses hypoxia-induced dedifferentiation of human NSCLC into cancer stem cell-like cells

  Miho Akimoto

  World Journal of Medical Genetics Baishideng Publishing Group Inc. 3 (4) 41 - 41 2220-3184 2013
• A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts.

  Koshi Kawakami; Miho Hattori; Takatsugu Inoue; Yuriko Maruyama; Junko Ohkanda; Nobuo Kato; Miki Tongu; Takaya Yamada; Miho Akimoto; Keizo Takenaga; Takeshi Sassa; Junji Suzumiy; Yoshio Honma

  Anti-cancer agents in medicinal chemistry BENTHAM SCIENCE PUBL LTD 12 (7) 791 - 800 1871-5206 2012/09 [Refereed]
  
• Cyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cells.

  Tsutomu Takahashi; Koshi Kawakami; Seiji Mishima; Miho Akimoto; Keizo Takenaga; Junji Suzumiya; Yoshio Honma

  Leukemia research PERGAMON-ELSEVIER SCIENCE LTD 35 (5) 638 - 45 0145-2126 2011/05 [Refereed]
  
• Gene Expression Profiles of Differentiating Leukemia Cells Induced by Methyl Jasmonate Largely Share with Those of Cytokinins and Methyl Jasmonate Analogs Induce the Differentiation of Human Leukemia Cells in Primary Culture

  Hiroto Tsumura; Miho Akimoto; Yuki Ishii; Hiromasa Kiyota; Hiroto Ishikura; Yoshio Honma

  Leukemia Springer Science and Business Media LLC 23 (4) 753 - 760 0887-6924 2009 [Refereed]
  
• Induction of differentiation of myeloid leukemia cells in primary culture in response to lithocholic acid acetate, a bile acid derivative, and cooperative effects with another differentiation inducer, cotylenin A.

  Akiyoshi Horie; Miho Akimoto; Hiroto Tsumura; Makoto Makishima; Takeshi Taketani; Seiji Yamaguchi; Yoshio Honma

  Leukemia research PERGAMON-ELSEVIER SCIENCE LTD 32 (7) 1112 - 23 0145-2126 2008/07 [Refereed]
  
• ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

  Kaori Ishikawa; Keizo Takenaga; Miho Akimoto; Nobuko Koshikawa; Aya Yamaguchi; Hirotake Imanishi; Kazuto Nakada; Yoshio Honma; Jun-Ichi Hayashi

  Science (New York, N.Y.) 320 (5876) 661 - 4 0036-8075 2008/05 [Refereed]
  
• Therapeutic strategy using phenotypic modulation of cancer cells by differentiation-inducing agents.

  Yoshio Honma; Miho Akimoto

  Cancer science BLACKWELL PUBLISHING 98 (11) 1643 - 51 1347-9032 2007/11 [Refereed]
  
• Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.

  Atsuko Kasahara; Kaori Ishikawa; Makiko Yamaoka; Masahito Ito; Naoki Watanabe; Miho Akimoto; Akitsugu Sato; Kazuto Nakada; Hitoshi Endo; Yoko Suda; Shinichi Aizawa; Jun-Ichi Hayashi

  Human molecular genetics OXFORD UNIV PRESS 15 (6) 871 - 81 0964-6906 2006/03 [Refereed]
  
• Rare creation of recombinant mtDNA haplotypes in mammalian tissues.

  Akitsugu Sato; Kazuto Nakada; Miho Akimoto; Kaori Ishikawa; Tomoko Ono; Hiroshi Shitara; Hiromichi Yonekawa; Jun-Ichi Hayashi

  Proceedings of the National Academy of Sciences of the United States of America NATL ACAD SCIENCES 102 (17) 6057 - 62 0027-8424 2005/04 [Refereed]
  
• Nuclear DNA but not mtDNA controls tumor phenotypes in mouse cells.

  Miho Akimoto; Mamoru Niikura; Masami Ichikawa; Hiromichi Yonekawa; Kazuto Nakada; Yoshio Honma; Jun-Ichi Hayashi

  Biochemical and biophysical research communications ACADEMIC PRESS INC ELSEVIER SCIENCE 327 (4) 1028 - 35 0006-291X 2005/02 [Refereed]
  

MISC

• Mechanisms of adrenal aging and enhancement of the Glucocorticoid-system

  奥平准之; 秋元美穂; 諏佐崇生; 秋元美穂; 小原幸弘; 久樹晴美; 飯塚眞由; 岡崎具樹; 安達(玉盛)三美  日本分子生物学会年会プログラム・要旨集(Web)  45th-  2022
• Dynamic expression changes of energy metabolism-related genes in mouse liver with aging.

  小原幸弘; 諏佐崇生; 秋元美穂; 奥平准之; 久樹晴美; 飯塚眞由; 岡崎具樹; 安達三美  日本分子生物学会年会プログラム・要旨集(Web)  45th-  2022
• HIF‐2α regulates susceptibility of human pancreatic cancer cells to TRAIL‐ and T cell‐mediated cytotoxicity via survivin

  HARASHIMA Nanae; AKIMOTO Miho; TAKENAGA Keizo; HARADA Mamoru  日本癌学会学術総会抄録集(Web)  74th-  E‐1238 (WEB ONLY)  2015  [Refereed]
  
• Inhibition of HIF‐2αsensitizes human pancreatic cancer cells to TRAIL

  HARASHIMA Nanae; HARI Yoko; MONMA Hiroyuki; AKIMOTO Miho; TAKENAGA Keizo; TAJIMA Yoshitsugu; HARADA Mamoru  日本癌学会学術総会抄録集(Web)  73rd-  E‐3032 (WEB ONLY)  2014  [Refereed]
  
• Augmenting sensitivity of cancer cells to novel antitumor fusicoccin derivative (ISIR-042) by hypoxia

  Yoshio Honma; Miho Akimoto; Keizo Takenaga; Takeshi Sassa; Nobuo Kato  MOLECULAR CANCER THERAPEUTICS  8-  (12)  2009/12
• Fusicoccin derivatives as therapeutic agents based on induction of differentiation

  Yoshio Honma; Miho Akimoto; Takeshi Sassa; Nobuo Kato  MOLECULAR CANCER THERAPEUTICS  6-  (12)  3391S  -3391S  2007/12
• マウスミトコンドリアDNAと造腫よう性の関係

  秋元美穂; 新倉保; 市川雅美; 米川博通; 中田和人; 本間良夫; 林純一  日本分子生物学会年会プログラム・講演要旨集  27th-  349  2004/11

Research Grants & Projects

• 肥満および老化の脂肪幹細胞由来のIL-33が膵がんの悪性進展に及ぼす影響の解析

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2022/04 -2025/03 

  Author : 秋元 美穂
• 低酸素による可溶性IL-33受容体の発現低下が大腸がん悪性進展に及ぼす影響の解析

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2019/04 -2023/03 

  Author : 秋元 美穂
• Expression of Parathyroid-specific Novel lncRNA and Paucity of CaSR Characterize an Ectopic PTH-producing Tumor.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2017/04 -2023/03 

  Author : 岡崎 具樹; 秋元 美穂
• Analysis of antitumor effects of adiponectin receptor agonists on pancreatic cancer

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2016/04 -2020/03 

  Author : Akimoto Miho
• Antimetastatic effects of a soluble IL-33 receptor and its utility as a prognostic biomarker in colorectal cancer.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/04 -2015/03 

  Author : AKIMOTO Miho