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Kinoshita Chisato

    Preclinical Medicine Senior Assistant Professor
    Department of Pharmacology Senior Assistant Professor
Last Updated :2025/05/17

Researcher Information

Affiliation

    Preclinical Medicine Senior Assistant Professor
    Department of Pharmacology Senior Assistant Professor

URL

J-Global ID

Research Interests

  • NOVA1   non-coding RNA   taurine   Circadian Rhythm   Neurodegenerative disease   RNA binding protein   GTRAP3-18   EAAC1   microRNA   Glutathione   

Research Areas

  • Life sciences / Pharmacology
  • Life sciences / Genomics
  • Life sciences / Nervous system function

Academic & Professional Experience

  • 2023/04 - Today  Teikyo University School of MedicineDepartment of Pharmacologyassociate professor/lecturer
  • 2009/06 - 2023/03  Teikyo University School of MedicineDepartment of PharmacologyAssistant Professor
  • 2007/04 - 2009/05  University of California, IrvinePostdoctoral Researcher

Education

  • 2004/04 - 2007/03  Tokyo Institute of Technology  Graduate School of Bioscience and Biotechnology  Department of Biomolecular Engineering
  • 2002/04 - 2004/03  Tokyo Institute of Technology  Graduate School of Bioscience and Biotechnology  Department of Biomolecular Engineering
  • 1998/04 - 2002/03  Tokyo Institute of Technology  School of Bioscience and Biotechnology

Association Memberships

  • THE JAPANESE PHARMACOLOGICAL SOCIETY   THE MOLECULAR BIOLOGY SOCIETY OF JAPAN   

Research Activity Information

Published Papers

Books etc

  • Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease 6th Edition
    Aoyama K; Kinoshita C; Nakaki T (Contributor65. Disorders of glutathione metabolism)Academic Press 2020/06
  • Tirotta E; De Mei C; Iitaka C; Ramos M; Holmes D; Borrelli E (Contributor12. Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice)Humana Press 2010 9781603273329 xii, 647 p.

Conference Activities & Talks

  • Chisato KinoshitaKoji AoyamaToshio Nakaki
    Neurological Disorders Summit 2023  2023/06
  • Chisato KinoshitaKazue Kikuchi-UtsumiKoji AoyamaRyo; SuzukiYayoi OkamotoNobuko; MatsumuraDaiki OmataKazuo MaruyamaToshio Nakaki
    RNA Therapeutics: From Concept to Clinic  2023/06
  • The effect of a miR-96-5p inhibitor delivery to brain using microbubbles and ultrasound technology on neuroprotection and autophagy activation.
    Chisato Kinoshita; Koji Aoyama; Ryo Suzuki; Nobuko Matsumura; Daiki Omata; Kazuo Maruyama; Toshio Nkaki
    Japan Basic and Clinical Pharmacology Week 2022  2022/11
  • The neuroprotective effect of a miR-96-5p inhibitor delivery to brain using microbubbles and ultrasound technology.
    Kinoshita C; Aoyama K; Nakaki T
    14th International Conference on Dementia, Alzheimer and Related Diseases  2022/09
  • Chisato Kinoshita; Koji Aoyoama
    The 95th Annual Meeting of the Japanese Pharmacological Society  2022/03
  • Increased glutathione via NOVA1 by administration of an inhibitor of the microRNA miR-96-5p
    Chisato Kinoshita; Nobuko Matsumura; Koji Aoyama; Toshio Nakaki
    The 94th Annual Meeting of the Japanese Pharmacological Society  2021/03
  • Increased GTRAP3-18 expression by miR-96-5p is mediated by a RNA-binding protein
    Chisato Kinoshita; Kazue Kikuchi-Utsumi; Nobuko Matsumura; Toshio Nakaki; Koji Aoyama
    The 93rd Annual Meeting of the Japanese Pharmacological Society  2020/03
  • Regulatory mechanisms of neuronal glutathione level by rhythmic microRNA expression
    Chisato Kinoshita; Koji Aoyama; Toshio Nakaki
    第42回日本分子生物学会年会  2019/12
  • miR-96-5p modulates RNA-binding proteins that down-regulate GTRAP3-18
    Chisato KINOSHITA
    The 92th Annual Meeting of the Japanese Pharmacological Society  2019/03
  • Dual Control of Glutathione Regulation in Neuroprotection
    Chisato KINOSHITA
    2nd Innovations and State of the Art In Alzheimer’s & Dementia Research  2018/07
  • GTRAP3-18 regulated by RNA-binding proteins under the control of microRNA
    Chisato KINOSHITA
    18th World Congress of Basic and Clinical Pharmacology  2018/07
  • Regulation of GTRAP3-18 by RNA-binding proteins modulated by microRNA
    Chisato KINOSHITA
    The 90th Annual Meeting of the Japanese Pharmacological Society  2017/03
  • Identification of negative regulatory factor of GTRAP3-18 modulated by miR-96-5p
    Chisato KINOSHITA
    The 89th Annual Meeting of the Japanese Pharmacological Society  2016/03
  • Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels
    Chisato KINOSHITA
    The 88th Annual Meeting of The Japanese Pharmacological Society  2015/03
  • Circadian Rhythm of a Neuroprotective System Regulated by microRNA in Mice
    Chisato KINOSHITA
    The 87th Annual Meeting of The Japanese Pharmacological Society  2014/03
  • A Circadian regulation of glutathione and its neuroprotective role in dopaminergic neuron
    Chisato KINOSHITA
    The 86th Annual Meeting of The Japanese Pharmacological Society  2013/03
  • Circadian regulation of neuroprotective role for glutathione in dopaminergic neuron
    Chisato KINOSHITA
    The 85th Annual Meeting of The Japanese Pharmacological Society  2012/03

MISC

Industrial Property Rights

  • 特開2022-25558:ｍｉＲ－９６－５ｐインヒビターとそれを含有する医薬組成物  2022/02/10
    中木 敏夫, 青山 晃治, 木下 千智, 松村 暢子, 内海 計, 杉山 亨, 森谷 俊介
  • US 10,308,936 B2:miR-96-5p inhibitor and a screening method for the inhibitor    2019/06/04
    Chisato Kinoshita, Toshio Nakaki
  • 特開2016-73249:miR-96-5p阻害剤とそのスクリーニング法  2016/05/12
    木下 千智, 中木 敏夫

Research Grants & Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2023/04 -2026/03 
    Author : 青山 晃治; 木下 千智; 松村 暢子; 杉山 亨
  • 日本学術振興会：科学研究費助成事業 基盤研究(C)
    Date (from‐to) : 2021/04 -2024/03 
    Author : 木下 千智
  • 日本学術振興会：科学研究費助成事業 基盤研究(C)
    Date (from‐to) : 2020/04 -2023/03 
    Author : 松村 暢子; 青山 晃治; 木下 千智
  • Neuroprotection of taurine against oxidative stress through miRNA regulation
    Takeda Science Foundation：Medical Research Grant
    Date (from‐to) : 2021/04 -2022/03
  • 帝京大学：帝京大学研究奨励助成金
    Date (from‐to) : 2019 -2020 
    Author : 木下 千智
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2017/04 -2019/03 
    Author : Kinoshita Chisato
  • 文部科学省：科学研究費 （若手研究(B)）
    Date (from‐to) : 2017 -2018 
    Author : 木下 千智
  • microRNAの分子機構解析による神経変性疾患の分子標的時間治療
    内藤記念科学振興財団：女性研究者研究助成金
    Date (from‐to) : 2016 -2018 
    Author : 木下 千智
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2015/04 -2017/03 
    Author : Kinoshita Chisato
  • 概日リズムを呈するmicroRNAによる神経保護効果
    文部科学省：科学研究費 （若手研究(B)）
    Date (from‐to) : 2015 -2016 
    Author : 木下 千智
  • 神経変性疾患の分子標的時間治療を目指したmicroRNAの分子機構解析
    帝京大学：研究奨励助成金
    Date (from‐to) : 2014 
    Author : 木下 千智
  • 神経変性疾患の時間治療を目指すmicroRNA解析
    興和生命科学振興財団：研究助成
    Date (from‐to) : 2014 
    Author : 木下 千智
  • 視交叉上核非依存性体内時計に関与するmicroRNA
    上原記念生命科学財団：研究奨励金
    Date (from‐to) : 2014 
    Author : 木下 千智
  • 脳機能障害の発生におけるドパミンD2 受容体の役割の解明
    内藤記念科学振興財団：海外研究留学助成金
    Date (from‐to) : 2006 
    Author : 木下 千智

Teaching Experience

  • ToxicologyToxicology Teikyo University