Tanaka Hiroo

Researcher Information

Affiliation

Preclinical Medicine Assistant Professor
Department of Pharmacology Assistant Professor

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201801006509505027

J-Global ID

• 201801006509505027

Research Interests

• 生体恒常性   上皮細胞   タイトジャンクション   細胞間バリア   細胞間チャネル   

Research Areas

• Life sciences / Cell biology

Academic & Professional Experience

• 2021/04 - Today  Teikyo UniversityAdvanced Comprehensive Research Organization
• 2019/04 - Today  Teikyo UniversitySchool of Medicine
• 2019/04 - 2021/03  Osaka UniversityGraduate School of Frontier Biosciences
• 2019/04 - 2021/03  Teikyo University
• 2018/04 - 2019/03  Osaka UniversityGraduate School of Medicine
• 2015/04 - 2017/03  Osaka UniversityGraduate School of Medicine
• 2013/04 - 2015/03  Osaka UniversityGraduate School of Medicine

Education

• 2003/04 - 2007/03  Osaka University  School of Science

Association Memberships

• 日本細胞生物学会   日本分子生物学会   日本生化学会   

Research Activity Information

Published Papers

• Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons

  Gen Shiratsuchi; Satoshi Konishi; Tomoki Yano; Yuichi Yanagihashi; Shogo Nakayama; Tatsuya Katsuno; Hiroka Kashihara; Hiroo Tanaka; Kazuto Tsukita; Koya Suzuki; Elisa Herawati; Hitomi Watanabe; Toyohiro Hirai; Takeshi Yagi; Gen Kondoh; Shimpei Gotoh; Atsushi Tamura; Sachiko Tsukita

  EMBO Reports Springer Science and Business Media LLC 2024/02
• Double mutation of claudin-1 and claudin-3 causes alopecia in infant mice.

  Koya Suzuki; Kosuke Yamaga; Reitaro Tokumasu; Tatsuya Katsuno; Hiroo Tanaka; Shuhei Chiba; Takeshi Yagi; Ichiro Katayama; Atsushi Tamura; Hiroyuki Murota; Sachiko Tsukita

  Annals of the New York Academy of Sciences 1523 (1) 51 - 61 2023/03
• The tight junction protein occludin modulates blood–brain barrier integrity and neurological function after ischemic stroke in mice

  Shintaro Sugiyama; Tsutomu Sasaki; Hiroo Tanaka; Haomin Yan; Takeshi Ikegami; Hideaki Kanki; Kumiko Nishiyama; Goichi Beck; Yasufumi Gon; Shuhei Okazaki; Kenichi Todo; Atsushi Tamura; Sachiko Tsukita; Hideki Mochizuki

  Scientific Reports Springer Science and Business Media LLC 13 (1) 2023/02
• Phase separation of an actin nucleator by junctional microtubules regulates epithelial function.

  Kazuto Tsukita; Manabu Kitamata; Hiroka Kashihara; Tomoki Yano; Ikuko Fujiwara; Timothy F Day; Tatsuya Katsuno; Jaewon Kim; Fumiko Takenaga; Hiroo Tanaka; Sungsu Park; Makoto Miyata; Hitomi Watanabe; Gen Kondoh; Ryosuke Takahashi; Atsushi Tamura; Sachiko Tsukita

  Science advances 9 (7) eadf6358  2023/02
• 脳卒中後の血液脳関門タイトジャンクションにおけるoccludinの役割(The role of occludin in Tight Junction in Blood Brain Barrier after stroke)

  Sugiyama Shintaro; Sasaki Tsutomu; Tanaka Hiroo; Yan Haomin; Kanki Hideaki; Tamura Atsushi; Tsukita Sachiko; Mochizuki Hideki

  臨床神経学 (一社)日本神経学会 61 (Suppl.) S226 - S226 0009-918X 2021/09
• A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction

  Tomoki Yano; Kazuto Tsukita; Hatsuho Kanoh; Shogo Nakayama; Hiroka Kashihara; Tomoaki Mizuno; Hiroo Tanaka; Takeshi Matsui; Yuhei Goto; Akira Komatsubara; Kazuhiro Aoki; Ryosuke Takahashi; Atsushi Tamura; Sachiko Tsukita

  The EMBO Journal EMBO 40 (2) 0261-4189 2020/12
• Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.

  Satoshi Konishi; Tomoki Yano; Hiroo Tanaka; Tomoaki Mizuno; Hatsuho Kanoh; Kazuto Tsukita; Toshinori Namba; Atsushi Tamura; Shigenobu Yonemura; Shimpei Gotoh; Hisako Matsumoto; Toyohiro Hirai; Sachiko Tsukita

  Life science alliance 2 (4) 2019/08 [Refereed]
  
• Morphologic determinant of tight junctions revealed by claudin-3 structures.

  Shun Nakamura; Katsumasa Irie; Hiroo Tanaka; Kouki Nishikawa; Hiroshi Suzuki; Yasunori Saitoh; Atsushi Tamura; Sachiko Tsukita; Yoshinori Fujiyoshi

  Nature communications 10 (1) 816 - 816 2019/02 [Refereed]
  
• The Claudins: From Tight Junctions to Biological Systems

  Tsukita S; Tanaka H; Tamura A

  Trends in Biochemical Sciences 44 (2) 141 - 152 2019/02 [Refereed]
  
• Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H pylori Infection.

  Koya Suzuki; Kazuhiro Sentani; Hiroo Tanaka; Tomoki Yano; Kazuo Suzuki; Masanobu Oshima; Wataru Yasui; Atsushi Tamura; Sachiko Tsukita

  Cellular and molecular gastroenterology and hepatology 8 (1) 119 - 142 2019 [Refereed]
  
• 胃のおける細胞間接着装置タイトジャンクションの長期障害と胃腫瘍の発生

  鈴木 浩也; 仙谷 和弘; 田中 啓雄; 矢野 智樹; 鈴木 和男; 田村 淳; 月田 早智子

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 91回 [3P - 279] 2018/09
• Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice.

  Tanaka H; Imasato M; Yamazaki Y; Matsumoto K; Kunimoto K; Delpierre J; Meyer K; Zerial M; Kitamura N; Watanabe M; Tamura A; Tsukita S

  Journal of Hepatology 69 (6) 1308 - 1316 0168-8278 2018/09 [Refereed]
  
• Site-specific distribution of claudin-based paracellular channels with roles in biological fluid flow and metabolism

  Hiroo Tanaka; Atsushi Tamura; Koya Suzuki; Sachiko Tsukita

  ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1405 (1) 44 - 52 0077-8923 2017/10 [Refereed]
  
• Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186

  Kosuke Fujimoto; Makoto Kinoshita; Hiroo Tanaka; Daisuke Okuzaki; Yosuke Shimada; Hisako Kayama; Ryu Okumura; Yoki Furuta; Masashi Narazaki; Atsushi Tamura; Shigetsugu Hatakeyama; Masahito Ikawa; Kiichiro Tsuchiya; Mamoru Watanabe; Atsushi Kumanogoh; Sachiko Tsukita; Kiyoshi Takeda

  MUCOSAL IMMUNOLOGY 10 (2) 446 - 459 1933-0219 2017/03 [Refereed]
  
• Claudin-21 Has a Paracellular Channel Role at Tight Junctions

  Hiroo Tanaka; Yasuko Yamamoto; Hiroka Kashihara; Yuji Yamazaki; Kazutoshi Tani; Yoshinori Fujiyoshi; Katsuhiko Mineta; Kosei Takeuchi; Atsushi Tamura; Sachiko Tsukita

  MOLECULAR AND CELLULAR BIOLOGY 36 (6) 954 - 964 0270-7306 2016/03 [Refereed]
  
• Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice

  Hiroo Tanaka; Maki Takechi; Hiroshi Kiyonari; Go Shioi; Atsushi Tamura; Sachiko Tsukita

  GUT 64 (10) 1529 - U209 0017-5749 2015/10 [Refereed]
  
• Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice.

  Kengo Matsumoto; Mitsunobu Imasato; Yuji Yamazaki; Hiroo Tanaka; Mitsuhiro Watanabe; Hidetoshi Eguchi; Hiroaki Nagano; Hayato Hikita; Tomohide Tatsumi; Tetsuo Takehara; Atsushi Tamura; Sachiko Tsukita

  Gastroenterology 147 (5) 1134 - 45 0016-5085 2014/11 [Refereed]
  
• Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1 beta, and Atrophic Gastritis in Mice

  Daisuke Hayashi; Atsushi Tamura; Hiroo Tanaka; Yuji Yamazaki; Shin Watanabe; Koya Suzuki; Kazuo Suzuki; Kazuhiro Sentani; Wataru Yasui; Hiromi Rakugi; Yoshitaka Isaka; Sachiko Tsukita

  GASTROENTEROLOGY 142 (2) 292 - 304 0016-5085 2012/02 [Refereed]
  
• Claudin-18の欠損はマウスのparacellar proton leak、IL-1の上昇、萎縮性胃炎を引き起こす(Deficiency of Claudin-18 cause paracellular proton leak,up-regulation IL-1and atrophic gastritis in mice)

  林 大祐; 田村 淳; 田中 啓雄; 山崎 裕自; 渡辺 慎; 鈴木 浩也; 鈴木 和男; 仙谷 和弘; 安井 弥; 猪阪 善隆; 楽木 宏実; 月田 早智子

  日本生化学会大会プログラム・講演要旨集 (公社)日本生化学会 84回 3P - 0565 2011/09
• Dual functional significance of calcineurin homologous protein 1 binding to Na+/H+ exchanger isoform 1

  Masafumi Matsushita; Hiroo Tanaka; Keiji Mitsui; Hiroshi Kanazawa

  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 301 (2) C280 - C288 0363-6143 2011/08 [Refereed]
  
• Predicted expansion of the claudin multigene family

  Katsuhiko Mineta; Yasuko Yamamoto; Yuji Yamazaki; Hiroo Tanaka; Yukiyo Tada; Kuniaki Saito; Atsushi Tamura; Michihiro Igarashi; Toshinori Endo; Kosei Takeuchi; Sachiko Tsukita

  FEBS LETTERS 585 (4) 606 - 612 0014-5793 2011/02 [Refereed]
  

MISC

• クローディンを基盤とするタイトジャンクションと生体システム構築の多様性

  田中啓雄; 田村淳; 矢野智樹; 月田早智子  膜タンパク質工学ハンドブック（監修 津本浩平、浜窪隆雄）  201  -210  2020/04  [Invited]
  
• Claudin-3の結晶構造が明らかにするタイトジャンクション形態の決定要素

  中村駿; 中村駿; 入江克雅; 入江克雅; 田中啓雄; 田村淳; 月田早智子; 藤吉好則; 藤吉好則  日本細胞生物学会大会(Web)  71st-  2019
• タイトジャンクションによる上皮細胞間バリア機能：クローディンを軸とした生体システム構築

  鈴木浩也; 田中啓雄; 田村淳; 月田早智子  実験医学  2017/04  [Invited]
  
• タイトジャンクションをターゲットとした消化管疾患治療の可能性

  田村淳; 田中啓雄; 鈴木浩也; 月田早智子  G.I.Research  2015/12  [Invited]
  

Research Grants & Projects

• Fundamental principles underlying the functional diversity of tight junctions

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2024/04 -2027/03 

  Author : 田中 啓雄
• Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Specially Promoted Research

  Date (from‐to) : 2019/04 -2024/03 

  Author : 月田 早智子; 中村 駿; 鈴木 貴; 後藤 慎平; 足立 誠; 田村 淳; 矢野 智樹; 田中 啓雄; 入江 克雅
• Astrocytes form tight junctions to organize blood brain barrier

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

  Date (from‐to) : 2021/04 -2023/03 

  Author : 田中 啓雄
• Tight junctions to organize apical membranes of epithelial cell sheets.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2019/04 -2021/03 

  Author : Tanaka Hiroo

Teaching Experience

医学英語Ⅰ医学英語Ⅰ Teikyo University, School of Medicine