高橋　宣治 (タカハシ　センジ)

研究者情報

所属

• 総合理工学科環境バイオテクノロジーコース 教授
• 大学院理工学研究科 教授
• 理工学研究科総合理工学専攻 教授

学位

• 理学博士（東京理科大学）

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202001005319568032

科研費研究者番号

• 00236291

J-Global ID

• 202001005319568032

研究キーワード

• 生物活性物質   天然物化学   

研究分野

• ライフサイエンス / 生物有機化学

経歴

• 2020年04月 - 現在  帝京大学理工学部 バイオサイエンス学科教授
• 2010年04月 - 2020年03月  帝京大学理工学部 バイオサイエンス学科准教授
• 2005年04月 - 2010年03月  帝京大学理工学部 バイオサイエンス学科講師
• 1991年04月 - 2005年03月  帝京大学理工学部 バイオサイエンス学科助手

学歴

• 1987年04月 - 1991年03月   東京理科大大学院   理学研究科   化学専攻 博士課程
• 1985年04月 - 1987年03月   東京理科大学 大学院   理学研究科   化学専攻 修士課程
• 1981年04月 - 1985年03月   東京理科大学   理学部   化学科

研究活動情報

論文

• A new metabolite, mannogeranylnerol, specifically produced at body temperature by Schizophyllum commune, a causative fungus of human mycosis.

  Shing Yiu Tam; Kenichi Uchida; Hirofumi Enomoto; Senji Takahashi; Koichi Makimura; Shohei Sakuda

  The Journal of antibiotics 75 4 243 - 246 2022年04月 [査読有り]
  
• Light dependent accumulation of beta-carotene enhances photo-acclimation of Euglena gracilis

  Yuri Tanno; Shota Kato; Senji Takahashi; Shun Tamaki; Shinichi Takaichi; Yutaka Kodama; Kintake Sonoike; Tomoko Shinomura

  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 209 2020年08月 [査読有り]
  
• Distribution of Flavan-3-ol Species in Ripe Strawberry Fruit Revealed by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging

  Hirofumi Enomoto; Senji Takahashi; Shiro Takeda; Hajime Hatta

  Molecules 25 1 103 - 103 2020年 [査読有り]
  
• Identification and functional analysis of the geranylgeranyl pyrophosphate synthase gene (crtE) and phytoene synthase gene (crtB) for carotenoid biosynthesis in Euglena gracilis

  Shota Kato; Shinichi Takaichi; Takahiro Ishikawa; Masashi Asahina; Senji Takahashi; Tomoko Shinomura

  BMC Plant Biology 16 1 2016年12月 [査読有り]
  
• Changes in polyamine levels in Xenopus early embryogenesis.

  K. Shiokawa; T. Mishina; H. Yoshida; J. Takai; K. Tsuboshima; T. Soutome; T. Terui; H. Abe; S. Sakurai; S. Takahashi; K. Tashiro; K. Igarashi

  Trends Develop. Biol. 7 25 - 31 2013年 [査読有り]
  
• Polyamines added to the culture medium of Xenopus fertilized eggs induce massive cell dissociation at the blastula stage by interfering with Ca2+-dependent cell adhesion.

  K. Shiokawa; T. Kondo; S. Takahashi; K. Igarashi

  Amino Acids. 45 3 571 - 572 2013年 [査読有り]
  
• Gene Expression in Pre-MBT Embryos and Activation of Maternally-Inherited Program of Apoptosis to be Executed at around MBT as a Fail-Safe Mechanism inXenopusEarly Embryogenesis

  Koichiro Shiokawa; Mai Aso; Takeshi Kondo; Hiroaki Uchiyama; Shinsaku Kuroyanagi; Jun-Ichi Takai; Senji Takahashi Masayuki Kajitani; Chikara Kaito; Kazuhisa Sekimizu; Eiji Takayama; Kazuei Igarashi; Hiroshi Hara

  Gene Regulation and Systems Biology 2 213 - 231 2008年01月 [査読有り]
  
• Byelyankacin : A Novel Melanogenesis Inhibitor Produced by Enterobacter sp. B20

  TAKAHASHI Senji; IWAI Hiroki; KOSAKA Kunio; MIYAZAKI Toshitsugu; OSANAI Yuko; ARAO Nakako; TANAKA Kouichi; NAGAI Koji; NAKAGAWA Akira

  Journal of antibiotics = An International Journal Devoted to Research on Bioactive Microbial Products 60 11 717 - 720 2007年 [査読有り]
  
• Biosynthesis of Quinolactacin A, a TNF Production Inhibitor

  Tatsuya Sasaki; Senji Takahashi; Kenichi Uchida; Shinji Funayama; Masatsune Kainosho; Akira Nakagawa

  The Journal of Antibiotics 59 7 418 - 427 2006年 [査読有り]
  
• Screening of Actinomycetes with Antinematodal Properties

  CHUBACHI KAZUYOSHI; FURUKAWA MAKOTO; FUKUDA SHIGEAKI; TAKAHASHI SENJI; YANAGISAWA TADASHI; ITAGAWA HIDEO; SHIMIZU TERUO; NAKAGAWA AKIRA

  Biocontrol science 7 1 49 - 54 The Society for Antibacterial and Antifungal Agents, Japan 2002年 [査読有り]
  
• Adxanthromycins A and B, New Inhibitors of ICAM-1/LFA-1 Mediated Cell Adhesion Molecule from Streptomyces sp. NA-148 : I. Taxonomy, Production, Isolation and Biological Activities

  NAKANO Takayuki; KOIWA Tsukasa; TAKAHASHI Senji; NAKAGAWA Akira

  Journal of antibiotics 53 1 12 - 18 2000年 [査読有り]
  
• Adxanthromycins A and B, New Inhibitors of ICAM-1/LFA-1 Mediated Cell Adhesion Molecule from Streptomyces sp. NA-148. II. Physico-chemical Properties and Structure Elucidation.:II. Physico-chemical Properties and Structure Elucidation

  TAKAHASHI SENJI; NAKANO TAKAYUKI; KOIWA TSUKASA; NOSHITA TOSHIRO; FUNAYAMA SHINJI; KOSHINO HIROYUKI; NAKAGAWA AKIRA

  The Journal of Antibiotics 53 2 163 - 170 JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 2000年 [査読有り]
  
• Quinolactacins A, B and C : Novel Quinolone Compounds from Penicillium sp. EPF-6 I. Taxonomy, Production, Isolation and Biological Properties

  KAKINUMA Norihiro; IWAI Hiroki; TAKAHASHI Senji; HAMANO Kunikatsu; YANAGISAWA Tadashi; NAGAI Koji; TANAKA Koichi; SUZUKI Kenichi; KIRIKAE Fumiko; KIRIKAE Teruo; NAKAGAWA Akira

  Journal of antibiotics 53 11 1247 - 1251 2000年 [査読有り]
  
• Quinolactacins A, B and C : Novel Quinolone Compounds from Penicillium sp. EPF-6 II. Physico-chemical Properties and Structure Elucidation

  TAKAHASHI Senji; KAKINUMA Norihiro; IWAI Hiroki; YANAGISAWA Tadashi; NAGAI Koji; SUZUKI Kenichi; TOKUNAGA Tatsuhiro; NAKAGAWA Akira

  Journal of antibiotics 53 11 1252 - 1256 2000年 [査読有り]
  
• Inhibitory Effect of Antimicrobial Agents on Alginate Production in Pseudomonas aeruginosa.

  HOSOYAMA TAKAYUKI; YUGE TAKEHIRO; TAKAHASHI SENJI; SUZUKI TOMOO; OKUBO TOYOJI; IYOBE SHIZUKO; NAKAGAWA AKIRA

  The Journal of Antibiotics 52 1 65 - 67 JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1999年 [査読有り]
  
• Adxanthromycin: A New Inhibitor of ICAM-1/LFA-1 Mediated Cell Adhesion from Streptomyces sp. NA-148

  KOIWA Tsukasa; NAKANO Takayuki; TAKAHASHI Senji; KOSHINO Hiroyuki; YAMAZAKI Mika; TAKASHI Tohru; AKAGAWA Akira

  Journal of antibiotics 52 2 198 - 200 1999年 [査読有り]
  
• Streptomyces sp.によるネコブセンチュウの防除: ネコブセンチュウを抑制する放線菌の探索およびポット試験/での有用性評価

  中鉢 一義; 古川 誠; 福田 重昭

  日本線虫学会誌 29 2 42 - 45 日本線虫学会 1999年 [査読有り]
  
• Pyridovericin and Pyridomacrolidin: Novel Metabolites from Entomopathogenic Fungi, Beauveria bassiana.

  TAKAHASHI SENJI; KAKINUMA NORIHIRO; UCHIDA KENICHI; HASHIMOTO RYUJU; YANAGISAWA TADASHI; NAKAGAWA AKIRA

  The Journal of Antibiotics 51 6 596 - 598 JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1998年 [査読有り]
  
• The Structures of Pyridovericin and Pyridomacrolidin, New Metabolites from the Entomopathogenic Fungus, Beauveria bassiana.

  TAKAHASHI SENJI; UCHIDA KENICHI; KAKINUMA NORIHIRO; HASHIMOTO RYUJU; YANAGISAWA TADASHI; NAKAGAWA AKIRA

  The Journal of Antibiotics 51 11 1051 - 1054 JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1998年 [査読有り]
  
• A Search for Pseudomonas Alginate Biosynthesis Inhibitors from Microbial Metabolites

  NAKAGAWA Akira; HOSOYAMA Takayuki; CHUBACHI Kazuyoshi; TAKAHASHI Senji; OHKUBO Toyoji; IYOBE Shizuko

  Journal of antibiotics 50 3 286 - 288 1997年 [査読有り]
  
• Melanoxazal, New Melanin Biosynthesis Inhibitor Discovered by Using the Larval Haemolymph of the Silkworm, Bombyx mori Production, Isolation, Structural Elucidation, and Biological Properties

  TAKAHASHI Senji; HASHIMOTO Ryuji; HAMANO Kunikatsu; SUZUKI Tomoo; NAKAGAWA Akira

  Journal of antibiotics 49 6 513 - 518 1996年 [査読有り]
  
• Biosynthesis of Lactacystin

  TAKAHASHI Senji; UCHIDA Kenichi; NAKAGAWA Akira; MIYAKE Yoko; KAINOSHO Masatsune; MATSUZAKI Keiichi; OMURA Satoshi

  Journal of antibiotics 48 9 1015 - 1020 JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1995年 [査読有り]
  
• A New Melanin Biosynthesis Inhibitor, Melanoxadin from Fungal Metabolite by Using the Larval Haemolymph of the Silkworm, Bombyx mori

  HASHIMOTO Ryuju; TAKAHASHI Senji; HAMANO Kunikatsu; NAKAGAWA Akira

  Journal of antibiotics 48 9 1052 - 1054 1995年 [査読有り]
  
• Biosynthesis of lactacystin. Origin of the carbons and stereospecific NMR assignment of the two diastereotopic methyl groups

  Akira Nakagawa; Senji Takahashi; Kenichi Uchida; Keiichi Matsuzaki; Satoshi Ōmura; Asao Nakamura; Noboru Kurihara; Tsuyoshi Nakamatsu; Yoko Miyake; Kanako Take; Masatsune Kainosho

  Tetrahedron Letters 35 28 5009 - 5012 1994年07月 [査読有り]
  
• New Method for Screening the Melanin Biosynthesis Inhibitor by Using the Larval Haemolymph of the Silkworm,Bombyx mori,and the Inhibitory Activity of Trichoviridin

  Hashimoto Ryuju; Takahashi Senji; Hamano Kunikatsu; Mori Tadasu; Nakagawa Akira

  Bioscience, Biotechnology, and Biochemistry 58 9 1725 - 1726 社団法人日本農芸化学会 1994年01月 [査読有り]
  
• Samarium (III) iodide promoted addition of diketene to aldehydes : A facile synthesis of δ-hydroxy-β-oxocarboxylates.

  Koji Abe; Senji Takahashi; Nobuo Mori

  Chemistry Express 6 3 193 - 196 1991年03月 [査読有り]
  
• Radical coupling of β-bromostyrene with carbonyl compounds promoted by samarium (II) di-iodide.

  Koji Abe; Katsuhiko Uehara; Senji Takahashi; Nobuo Mori

  Chemistry Express 6 3 189 - 192 1991年03月 [査読有り]
  
• Reductive cross-coupling of pyruvates with carbonyl compounds mediated by SmI2 : A facile synthesis of α,β-dihydroxycarboxylates.

  Koji Abe; Senji Takahashi; Nobuo Mori

  Chemistry Express 6 1 53 - 56 1991年01月 [査読有り]
  
• Samarium(II) diiodide mediated coupling of bis(bromomethyl)arenes. Facile synthesis of [2n]cyclophanes without using high-dilution techniques

  Senji Takahashi; Nobuo Mori

  Journal of the Chemical Society, Perkin Transactions 1 8 2029 - 2032 1991年 [査読有り]
  
• Novel transannular reactions in the acid hydrolysis of diazotized syn- and anti-4-amino[2.2] (1,4)naphthalenoparacyclophanes

  Yoshihiro Takada; Kazuhiko Tsuchiya; Senji Takahashi; Nobuo Mori

  Journal of the Chemical Society, Perkin Transactions 2 12 2141 - 2145 1990年 [査読有り]
  
• A Simple Synthetic Method of [2.2]Cyclophanes by Lanthanoid-Mediated Coupling of Bis(bromomethyl)benzenes

  Senji Takahashi; Nobuo Mori

  Chemistry Letters 18 1 13 - 14 1989年01月 [査読有り]
  

共同研究・競争的資金等の研究課題

• 微生物の有する生合成機能解明による新規抗生物質の創製に関する研究

  日本学術振興会：科学研究費助成事業

  研究期間 : 1992年 -1993年 

  代表者 : 中川 彰; 高橋 宣治